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  Topotecan Injection 4.5 mg
  Indications :
 

Metastatic carcinoma of the ovary after failure of initial or subsequent chemotherapy.

Small cell lung cancer after failure of first-line chemotherapy.

Stage IV-B, recurrent or persistent carcinoma of the cervix (which is not amenable to curative treatment with surgery and/or radiation therapy).

   
  Dosage :
 

Cervical Cancer : IV 0.75 mg/m² daily infused over 30 min on days 1, 2, and 3, followed by IV cisplatin 50 mg/m² infused on day 1 repeated every 21 days.

Ovarian or Small Cell Lung Cancer : IV 1.5 mg/m² /day over 30 min daily for 5 consecutive days starting on day 1 of a 21-day cycle.

Dosage Adjustment :

Renal Impairment : Required.

Hepatic Impairment : No dosage adjustment is required in patients with plasma bilirubin > 1.5 but < 10 mg/dl.

   
  Packing : 10 Vials of 4.5 mg/4.5 ml
 



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