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Tirofiban Hydrochloride Injection 5 mg |
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In Patients with acute coronary syndrome, who have
- Cardiac Pain without persistent ECG ST-segment elevation.
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Ischaemic ECG ST-segment depression; or raised cardiac Troponin T>0.1 ug/l (i.e. Patients with Non-ST elevation MI-NSTEMI).
In High risk patients having raised cardiac Troponin T>0.1 ug/l with either one of the following :
- Ischaemic ST segment depression while receiving treatment with aspirin/ heparin/medical Anti- ischaemic agents.
- Post-infarction (< 2 weeks) new ischaemic ECG ST-segment depression.
- Transient ECG ST-segment elevation not receiving thrombolytic treatment.
- Ischaemic ECG ST-segment changes associated with haemo-dynamic instability.
- Ischaemic ECG ST-segment changes associated with major arrythmias (recurrent ventricular tachycardia, ventricular fibrillation).
Patients with acute coronary syndromes referred for emergency PCI (Percutaneous Coronary Angioplasty/ Stent Implantation) for recurrent or refractory myocardial ischaemia.
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Administration :
Use Tirofiban within 12 hrs of the last episode of the chest pain or ischaemic ECG changes. Use Tirofiban in combination with aspirin and heparin.
Dosage :
It should be administered intravenously, at an initial rate of 0.4 mcg/kg/min for 30 minutes and then continued at 0.1 mcg/kg/min for between 48 and 108 hrs (2-4.5 days).
Continue upto and during coronary angioplasty/ stenting if undertaken, and for atleast 12-24 hrs afterwards.
Renally Impaired Patients : Patients with severe renal insufficiency (creatinine
clearance <30 mL/min) should receive half the usual rate of infusion. |
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Packing : |
1 Vial of 5 mg/100 ml |
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