Ribavirin must be used in combination with either peginterferon alfa-2b or interferon alfa-2b.

The dose of Ribavirin is based on patient body weight.

Ribavirin capsules are to be administered orally each day in two divided doses (morning and evening) with food.

Adults : The dose of Ribavirin is based on patient body weight.
Ribavirin must be used in combination with either peginterferon alfa-2b (1.5 micrograms/kg/week) or interferon alfa-2b (3 million international units [MIU] three times a week). The choice of combination regimen is based on the characteristics of the patient.

Children 3 years of age & older and adolescents : Dosing for children and adolescent patients is determined by body weight for Ribavirin and by body surface area for peginterferon alfa-2b and interferon alfa-2b.

Renally Impaired Patients : Dosage adjustment required.