Adults :

Children : 50 to 400 mcg /Kg/Day in 2-3 divided doses.

Mild disorders : No dosage adjustment is required.

Moderate to severe disorder : The therapy is initiated at 500mcg daily and then increased cautiously.

Dosage Adjustment :

Renal Impairment : May be required in severe impairment.

Hepatic Impairment : May be required in severe impairment.