AS SINGLE THERAPY : 12 - 14 mg/m² once a month or every 35 days by intravenous infusion.
The crystals are dissolved in 200 mL of a 5% glucose solution which is then administered over a period of 30 minutes, preferably with Vitamin B Compound.
AS COMBINATION THERAPY : 10 mg/m² every 6 - 9 weeks. Higher doses have also been given.
Mitomycin-C is usually administered along with other agents (e.g. FOAM –5 FU plus vincristine plus doxorubicin plus mitomycin; SMF –streptozotocin plus mitomycin plus 5 FU; AM – doxorubicin plus mitomycin; FAM –5 FU plus doxorubicin plus mitomycin).
Dosage Adjustment :
Renal Impairment : Required.
Hepatic Impairment : Not necessary but administer with caution. |
