May be administered by IV or IM injection or by IV infusion. The preferred method for initial
emergency is IV injection.

Usual Doses : 30mg/kg administered IV over atleast 30 minutes. This dose may be repeated every 4-6 hour for 48 hours.

Initial Doses : 10-40mg IV over a period of several minutes. The larger doses may be required for short term management of severe, acute conditions.

In Multiple Sclerosis : 200mg for a week followed by 80mg every other day for one month.

In Renal Transplantation :
- For induction of Immunosuppression : Start with 80-160mg OD for three days followed by oral therapy.

- In treatment of acute rejection : 500 mg upon diagnosis, followed by 500 mg OD for two days.

Acute Spinal Cord Injury : 30 mg/kg bolus followed by 5.4 mg/kg  bolus for 24-48 hours.

Prevention of ARDS and Fat Embolism syndrome : 30 mg/kg body weight can be repeated after 6 hours.