In Multiple Sclerosis
1g/day I.V. for 3-5 days.

In Optic Neuritis
1g/day I.V. for 3 days followed by oral prednisolone therapy.

In Renal transplantation
a ) For induction of Immunosuppression : Start with 80-160 mg OD for three days followed by oral therapy.
b ) In treatment of acute rejection: 500 mg upon diagnosis, followed by 500 mg OD for two days.

Oedematous states
30 mg/kg body weight every other day for 4 days or 1gm /day for 3, 5 or 7 days I.V.

Acute Spinal cord injury
30 mg /kg bolus followed by 5.4 mg/kg bolus for 24-48 hours.

Prevention of ARDS and Fat Embolism syndrome
30 mg /kg body weight can be repeated after 6 hours.